Fab:=21Tr[ρ{La,Lb}] where: Tr is the Trace Operator {A,B}:=AB+BA is the anti-commutator. ρ is a Density Operator, described through set of parameters x=(x1,x2,…,xk), so that ρ=ρ(x). La and Lb are the Symmetric Logarithmic derivative, satisfying the equation ∂aρ:=21(ρLa+Laρ).